Therapeutic Oligonucleotides: RSC (RSC Biomolecular Sciences) read pdf | bukmekerskajakontora.ru

May 22, 2008 · Oligonucleotides are a promising new class of biomacromolecules for various therapeutic purposes to treat cancer, viral infections and inflammatory diseases. Antisense oligonucleotides against the cytomegalovirus and an aptamer to treat an ocular disease have already been approved by the regulatory authorities. Therapeutic Oligonucleotides RSC Publishing This book provides a comprehensive overview of the development of therapeutic oligonucleotides for therapeutic applications, touching on a number of additional oligonucleotides including a number of small interfering RNAs currently in various phases of clinical development. THERAPEUTIC OLIGONUCLEOTIDES: RSC RSC BIOMOLECULAR SCIENCES By Stephen Neidle, David M J Lilley, Simon Campbell, Marius Clore, Roderick E Hubbard, C A Stein, Michael J Gait, Troels Koch, Eugen Uhlmann, Noah Kornblum, Sven Klubmann, Ben Berkhout, Johnathan Lai, Henry Fechner, Ian Maclachlan, John Rossi, Luba NEW.

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide. This book provides a comprehensive overview of the development of therapeutic oligonucleotides for therapeutic applications, touching on a number of additional oligonucleotides including a number of small interfering RNAs currently in various phases of clinical development. Morpholinos or phosphorodiamidate morpholino oligomers PMOs are antisense compounds. Their efficacy, sequence specificity, stability and low toxicity have been demonstrated in many publications pubs.gene

RSC Biomolecular Sciences 2005-2012 A collection of books edited by leading international scientists working in the field providing an authoritative resource for researchers and postgraduate students in biochemistry, biophysics and molecular biology. A collection of books edited and written by leading international scientists working in the field, the RSC Biomolecular Sciences Set provides an authoritative and definitive collection of reference guides for graduate and postgraduate students and researchers in biochemisty, biophysics and molecular biology. The RSC Biomolecular Sciences Series is devoted to the coverage of the interface between the chemical and biological sciences, especially structural biology, chemical biology, bio- and chemo-informatics, drug discovery and development, chemical enzymology and biophysical chemistry. The books are ideal for.

Biomaterials Science is a n international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions. Sep 15, 2011 · James L. Scotson, Benjamin I. Andrews, Andrew P. Laws, Michael I. Page, Phosphorothioate anti-sense oligonucleotides: the kinetics and mechanism of the generation of the sulfurising agent from phenylacetyl disulfide PADS, Organic & Biomolecular Chemistry, 10.1039/C6OB01531J, 14, 35, 8301-8308, 2016. Dec 01, 2017 · In this review, two different applications of aptamers in therapeutic development are discussed.First is the use of aptamers as therapeutic agents that act by binding to targets such as receptors, enzymes, host cells, and pathogens [13, 14].Second is the use of aptamers for targeted delivery of therapeutic molecules such as small molecule drugs, nanoparticles, and genes [15, 16, 17].

Recently, P-boronated oligonucleotides have been attracting much attention as potential therapeutic oligonucleotides. In this study, we developed H-boranophosphonate oligonucleotide bearing a borano group and hydrogen atom on the internucleotidic phosphorus and demonstrated that this novel P-boronated oligonucleotide is a versatile precursor to various P-boronated oligonucleotides such as. ISBN: 9780854041169 0854041168: OCLC Number: 213112124: Description: xvii, 343 pages: illustrations some color; 24 cm. Contents: The role of backbone modifications in oligonucleotide-based strategies --Genasense G3139: an antisense Bcl-2 oligodeoxyribonucleotide with substantial clinical activity and a complex mechanism of action --Antisense morpholino oligomers and their peptide.

ISBN: 9780854041169 0854041168: OCLC Number: 237326966: Description: xvii, 343 pages: illustrations some color; 24 cm. Contents: The role of backbone modifications in oligonucleotide-based strategies --Genasense G3139: an antisense Bcl-2 oligodeoxyribonucleotide with substantial clinical activity and a complex mechanism of action --Antisense morpholino oligomers and their peptide.

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