ISBN: 0854033580 9780854033584: OCLC Number: 18326736: Description: viii, 436 pages: Other Titles: Philosophical transactions of the Royal Society of London. philosophical transactions of the royal society of london b. biological sciences issn 0080-4622 volume 320 pages 235-436 number 1199 26 july 1988 inositol lipids and transmembrane signalling a discussion organized and edited by m. j. berridge, f.r.s., and r. h. michell, f.r.s. published by the royal society 6 carlton house terrace london sw1y 5ag. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, Vol. 320, No. 1199, Jul. 26, 1988. If the address matches an existing account you will receive an email with instructions to reset your password.
Inositol lipids and transmembrane signalling: Proceedings of a Royal Society discussion meeting, held on 2 and 3 December 1987 Philosophical transactions of the Royal Society of London Published by Distributed by Scholium International 1988. Other candidates are the calcium and hydrogen ions whose concentrations change dramatically during the action of most growth factors, many of which also stimulate the hydrolysis of inositol lipids. In particular, certain growth factors stimulate the hydrolysis of phosphatidylinositol 4,5- bisphosphate to give the two second messengers. Nov 20, 2015 · Among different inositol lipids, the importance in transmembrane signaling and regulation of cell functions are best documented for PtdIns4,5P2 and PtdIns3,4,5P3.
Finally, from the specific inhibitory action of pertussis toxin on THR- and 5-HT-induced DNA synthesis, and from the exploitation of the 5-HT pharmacological tools, we conclude that: i there are at least two distinct Gproteins involved in signalling growth: G p, coupling receptors to PtdIns4,5P 2-PLC, and G 1 coupling receptors negatively. Berridge, M.J. and Irvine R.F. Inositol trisphosphate, a novel second messenger in cellular signal transduction, Nature 312 1984, 315–321. PubMed CrossRef Google Scholar.
Inositol lipids and phosphates R.H. Michell Department of Biochemistry, University of Birmingham, Birmingham, UK Current Opinion in Cell Biology 1989, 1:201-205 Introduction it has been about 5 years since it was widely accepted that receptor-activated hydrolysis of phosphatidylinositol 4,5-bisphosphate Ptdlns4,5P2 by phosphoinositidase C PIC, yielding the second messengers 1,2. Jun 20, 2017 · Among different inositol lipids, the importance in transmembrane signaling and regulation of cell functions are best documented for PtdIns4,5P2 and PtdIns3,4,5P3. There are several ways in which these low-abundance inositol lipids less than 1% of membrane phospholipids could provide a signaling link or fulfill other roles in different. We review the evidence that this signalling system is also composed of three types of proteins: receptor, G-protein and effector. The G-protein that couples to the effector, polyphosphoinositide phosphodiesterase PPI-PDE, is a novel G-protein, G_p, which is a substrate for pertussis toxin in some cells e.g. neutrophils and platelets but not.
A major decoding mechanism employed by a variety of hormones, neurotransmitters and growth factors depends on the hydrolysis of a unique inositol lipid to generate two key second messengers, diacylglycerol and inositol 1, 4, 5-trisphosphate Ins1, 4, 5P 3. Inositol lipids are important for lipid composition and homeostasis. The central role of inositol lipids in transmembrane signaling, ion channel regulation and cellular trafficking has been well established 1.However, in addition to these well-recognized roles, inositol lipids are repeatedly linked to processes affecting general lipid composition and homeostasis. Dafna Lipinsky, Marvin C. Gershengorn, Yoram Oron, Latency in the inositol lipid transduction pathway: the role of cellular events in responses to thyrotropin-releasing hormone in Xenopus oocytes, Pfl gers Archiv European Journal of Physiology, 10.1007/BF00374514, 425, 1-2, 140-149, 1993.
Berridge M 1997 The Croonian Lecture, 1988 - Inositol lipids and calcium signalling, Proceedings of the Royal Society of London. Series B. Biological Sciences, 234:1277, 359-378, Online publication date: 22-Sep-1988. The mechanisms of growth factor action were studied in a fibroblastic cell line capable of reversible growth arrest in G0-G1. This cell line, derived from Chinese hamster lung, can be stimulated to divide by a limited set of purified growth factors, including EGF, FGF, PDGF, α-thrombin THR, serotonin 5-HT and insulin. THR and 5-HT stimulate, via a G-protein G_p, a polyphosphoinositide. philosophical transactions of the royal society of london b. biological sciences issn 0080-4622 volume 327 pages 65-221 number 1239 12 march 1990 growth factors in differentiation and development a discussion organized and edited by m.j. crumpton, f.r.s., and t. m. dexter published by the royal society 6 carlton house terrace london swiy 5ag i. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis is an important signalling reaction involved in the responses of cells to some, but not all, stimuli that promote cell proliferation. Active agents in this regard include antigens activating T and B lymphocytes, angiotensin employing a receptor encoded by the mas oncogene, bombesin and platelet-derived growth factor PDGF.
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 1934-1990 Vol. 224, No. 509 - Vol. 328, No. 1251. Inositol lipids in cell signalling. London; San Diego: Academic Press, 1989 OCoLC571320182 Online version: Inositol lipids in cell signalling. London; San Diego: Academic Press, 1989 OCoLC607841572: Material Type: Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors: R H Michell; Alan H Drummond; C Peter. The Royal Society is collaborating with JSTOR to digitize, preserve, and extend access to Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. PDF On Mar 1, 1989, ROBERT H. MICHELL published Inositol lipids and phosphates in growing, stimulated and differentiating cells Find, read and cite all the research you need on ResearchGate. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B VOLUME 320 BIOLOGICAL SCIENCES 1988 PUBLISHED BY THE ROYAL SOCIETY 6 CARLTON HOUSE TERRACE LONDON SWIY 5AG. ISSN 0080-4622. Inositol lipids and transmembrane signalling A Discussion organized and edited by M. J. BERRIDGE, F.R.S., and.
The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions, Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 10.1098/rstb.1981.0177, 296, 1080, 123-138, 1997. Transmembrane signalling from cell surface receptors occurs by two broad mechanisms: i the rapid ms direct opening of an ion channel, where the ion channel is a component of the receptor complex e.g. the nicotinic acetylcholine receptor; and ii the more slow s modulation of a membrane enzyme or more distant ion channel. Oct 01, 1984 · Journal of Clinical Investigation 63, 580-587. 33. Nishizuka, Y. 1983. Calcium, phospholipid turnover and transmembrane signalling. Philosophical Transactions of the Royal Society of 472 London Series B - Biological Sciences 302, 101-112. 34. Michell, R.H. 1975. Inositol phospholipids and cell surface receptor function. Our current knowledge of the process by which receptors stimulate the hydrolysis of phosphatidylinositol 4,5-bisphosphate PtdIns4,5P_2 has its origin in the discovery by Hokin & Hokin J. biol. Chem. 263, 967 1953 that some pancreatic secretagogues not only elicit exocrine secretion but also stimulate the metabolism of membrane phospholipids. Despite the recent elucidation of many. Cell Calcium 3: 285-294, 1982 STIMULATED INOSITOL LIPID METABOLISM: AN INTRODUCTION Robert H. Michell Department of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham B'15 2TT, UK It is now more than half a century since the first description of a glycerophospholipid containing approximately equimolar amounts of inositol and phosphate 1-3, and a third of a century since Folch.
The highly dynamic membranous network of eukaryotic cells allows spatial organization of biochemical reactions to suit the complex metabolic needs of the cell. The unique lipid composition of organelle membranes in the face of dynamic membrane activities assumes that lipid gradients are constantly generated and maintained. Important advances have been made in identifying specialized membrane. Michell, R.H., Kirk, C.J., Jones, L.M. et al. 1981 The stimulation of inositol phospholipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions. Philosophical Transactions of the Royal Society of London, Series B,. Aug 01, 1990 · Mauco G, Dajeans P, Chap H, Douste-Blazy L. Subcellular localization of inositol lipids in blood platelets as deduced from the use of labelled precursors. Biochem J. 1987 Jun 15; 244 3:757–761. [PMC free article] Michell RH. Inositol phospholipids and cell surface receptor function. Biochim Biophys Acta. 1975 Mar 25; 415 1:81–47. Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses.Lipid signaling is thought to be qualitatively different from other classical signaling paradigms such as monoamine neurotransmission. As new techniques are developed to measure intracellular messengers it becomes increasingly apparent that there is a remarkable spatial and temporal organization of cell signalling. Cells possess a small discrete hormone-sensitive pool of inositol lipid. In some cells such as Xenopus oocytes and Limulus photoreceptors this phosphoinositide signalling system is highly concentrated in one region.
Inositol lipids are important for lipid composition and homeostasis The central role of inositol lipids in transmembrane signal-ing, ionchannelregulation,andcellulartrafﬁckinghasbeen well established . However, in addition to these well-recognized roles, inositol lipids are repeatedly linked to processes. Among different inositol lipids, the importance in transmembrane signalling and regulation of cell functions are best documented for PtdIns 4,5P2 and PtdIns3,4,5P3. There are several ways in which these low abundance inositol lipids less that 1% of membrane phospholipids could provide a signalling link or fulfill other roles in different cellular processes. Dec 01, 1990 · European Journal of Clinical bTvestigation 14:37 Abstract 222. Davies MJ & Thomas T 1981 The pathological basis and microanatomy of occlusive thrombus formation in human coronary arteries. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences London294: 225-229.
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences [01 Jul 1988, 3201199:427-436]. In the present study, we identify signalling through the inositol 1,4,5-trisphosphate receptor IP 3 R Figure 1A as a specific component, required for a small subset of ASH-mediated responses. IP 3 Rs in Caenorhabditis elegans are encoded by a single gene, itr-1, and are widely expressed throughout the animal, including in the nervous. Rat liver plasma membranes are enriched in a Ca2‐dependent phosphodiesterase active on phosphatidylinositol 4,5‐P2 and phosphatidylinositol 4‐P, but not phosphatidylinositol. Inositol.
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